BIOGRAPHY
Dr. SoonGweon Hong is a Post Doctoral researcher for BSAC, where he focuses on organ-on-a-chip, diagnostics, nanoplasmonic-based spectroscopic sensor development, and microfluidic-based biochip design.

Prior to joining BSAC, Dr. Hong was an associate manager for Hyundai Heavy industries. During his time there he worked on development of information architecture and systemic design of destroyers and submarines.

Dr. Hong received his undergraduate degree from Seoul National University in 2002.

Investigation of Dengue Infection’s Neurological Complications via a Comprehensive In Vitro Brain Model [BPN824]
Dengue fever is one of global health concerns as two fifth of world population are
considered to expose to the infection risk and 20K patients results in death per year. Even
after successful recovery from the febrile disease, it often causes secondary neurological
complications including encephalopathy, residual brain damage and seizures. However, unclear
etiological details of neurological disorders still inhibit to uncover suitable treatments of
the complications. Herein, we develop an in-vitro brain model for the comprehensive
systematic analysis of neurological complications due to of the Dengue infections. Our
new minibrains-on- a-chip concept will allow to mature brain tissue mimicking in-vivo
tissue complex in an interstitial fluidic dynamics and to monitor electrophysiological
phenotypes in an in-situ manner. By administrating various etiological factors found in
dengue virus (DENV) infection along with the dynamic flow, we will be able to address
phenotypic connections of individual etiological factors. Our integrated in- vitro brain
model analysis platform for Dengue infections will potentially provide a diagnostic and
therapeutic frame for various levels of neurological disease associated with DENV
infection.