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Amy Liao, Ph.D. 2017

Bioengineering
Advisor: Prof. Maharbiz

BIOGRAPHY
Amy Liao received a B.S. in Biomedical Engineering from Rice University in 2012. At Rice, she worked on developing and optimizing a multiplexed microfluidic immunoassay to diagnosis ovarian cancer. For her senior thesis, she designed a low-cost, portable endoscope for use in the developing world. Amy is currently pursuing a Ph.D. in Biomedical Engineering at UC Berkeley, with an emphasis in biomedical instrumentation. Her projects include an electronic bandage for monitoring and prevention of pressure ulcers and a strain sensor to guide and track hernia repairs.

Full-Field Strain Sensor for Hernia Mesh Repairs [BPN765]
Each year, more than 400,000 ventral hernia repairs are performed in the United
States. A hernia is the protrusion of an organ through a weak spot in the surrounding muscle
or connective tissue that normal contains it. Large ventral hernias (hernias that occur in the
abdominal wall) are typically treated by suturing in a surgical mesh to cover and overlap the
hernia defect. The surgical mesh provides additional support to the damaged tissue surrounding
the hernia. However, in 25-40% of patients, the hernia repair fails, resulting in recurrence of
the hernia, along with other complications including infection and intestinal obstruction. We
hypothesize that a major cause of hernia recurrence is the unequal distribution of stress
across the mesh resulting in high stress concentrations at the tissue-mesh interface,
particularly at the site of mesh fixation to the abdominal wall muscles. Over time the mesh is
pulled away from the abdominal wall at the high stress concentrations and the hernia defect
recurs. We propose to design a biocompatible, instrumented patch, capable of mapping the 2D
strain topography placed on the mesh. The sensor will enable surgeons to actively identify and
address areas of high stress during the surgery by modifying the surgical procedure to
redistribute stress more evenly, thus decreasing the rate of hernia recurrence. Furthermore,
our long term goal is to design a hernia mesh that contains strain gauges and the associated
circuitry such that once implanted in the body the prosthetic can alert patients when they are
engaging in activities that place high stress on the implant. Such a dynamic, interactive
hernia mesh would empower patients to actively participate in their post-operative care in a
way that is personalized and unprecedented in surgery.


Current Active Projects:
BPN714
BPN765
 

     Last Updated: Thu 2016-Jan-21 16:57:07

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