Research Interests: Biosensors for point of care clinical diagnostics,
Inovative MEMs devices for clinical diagnostics and drug delivery applicationsJob Interests: Industry R & D
Dr. Kiana Aran received her Ph.D in Biomedical Engineering from Rutgers University in 2012. Dr. Aranís research focuses on the development of MEMs devices for point of care clinical diagnostics and health management. Her research combines polymeric science with MEMs systems to create novel device solution for disease diagnostics and drug delivery. Dr. Aran has expertise in microfluidics, microdevice design and fabrication as well as experience in novel polymer design for development of stimuli responsive material to be incorporated in MEMs devices for biological applications.
Biosensors Based on Biologically Responsive Polymers [BPN757]
This project presents the design, fabrication and testing of a novel lab-on-a-chip (LOC) sensor which utilizes a novel stimuli responsive polymer for early detection of circulating reactive oxygen species (ROS) such as hydroperoxides in blood. The portable lab-on-a-chip sensor, termed ROC, is composed of interdigitated electrodes (IDE) coated with a thin film of ROS responsive polymer. ROS leads to cleavage of the cross-linking moiety and degradation of the polymer from the surface of the IDE, and generates a measurable electrical signal that correlates with the amount of hydroperoxides present in the sample. Circulating hydroperoxides mainly lipid hydroperoxides are the primary biomarker of lipid oxidation, which lead to cell damage, inflammation and accumulation of lipid-loaded macrophages, key mediators in development of atherosclerosis. Moreover, circulating lipid hydroperoxides can predict cardiovascular events in patients with a history of cardiovascular diseases. Conventional fluorescence assays to quantify the amount of hydroperoxides in blood are expensive, require advanced instrumentation and have low sensitivity. This technology can be utilized as an accurate, cost-effective, and fast mean of assessing and monitoring lipid hydroperoxides, for effective management of cardiovascular diseases in routine clinical practices.