BERKELEY SENSOR & ACTUATOR CENTER
UC BERKELEY UC DAVIS
User: Guest |  Site Map |  My BSAC Profile
HOME  PROJECTS  THRUSTS  PUBLICATIONS  ABOUT BSAC  DIRECTORY  ALUMNI  FOR BSAC RESEARCHERS  EVENTS CALENDAR  SECURE LOGIN
Alumni
     
 
ByungRae Cho, Ph.D. 2018

BioEngineering
Advisor: Prof. Lee
(510) 666-3352

BIOGRAPHY

A Rapid, Integrated Molecular Diagnostic for Gram-Negative Pathogen Detection and Identification Based on Antibody-Based Capture and Photonic PCR [BPN804]
The fast and precise detection and identification of pathogens has become significantly important in medicine,
food safety, public health, and security. However, the conventional testing (bacteria cultures with several antibiotics
for susceptibility test) needs one to four days to acquire the result. Here, we develop an integrated molecular
diagnostic system that combines sample preparation, pathogen lysis, and genetic detection to identify pathogens
within a few hours. Bacteria in relatively large-volume sample (3-5 mL) continuously passing through a fluidic
channel are captured and identified by antibodies on the gold-coated nanopore membranes within 30 min. Gold -
coated membranes can easily raise the temperature beyond 70 degrees Centigrade under LED light emission
enabling rapid pathogen lysis. Combining with temperature control and photonic system, PCR can be executed for
genetic detection of pathogen within 5 min. We expect that this integrated molecular diagnostic system will provide
rapid diagnosis of pathogen infection and contribute to precision medicine.


Current Active Projects:
BPN804
BPN730
 

     Last Updated: Mon 2016-Jan-25 19:49:59

back to Researchers



 

  • Copyright Notification: All papers downloaded from this site are © University of California or the publisher, all rights reserved. Contact the BSAC Webmaster for permission related to copyrighted materials.
  • Links on these pages to commercial sites do not represent endorsements by UC or its affiliates.
  • Privacy Policy
  • Contact Us

   webmaster@bsac.eecs.berkeley.edu
  User logged in as: Guest
  User Idle since: February 8, 2016, 2:14 am