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Efthymios Papageorgiou, Ph.D. 2019

Electrical Engineering
Advisor: Prof. Boser
Research Interests: Micro Fluorescence Imager for Real-Time In-Vivo Breast Cancer Detection: Successful treatment of early stage cancer depends on the ability to resect both gross and microscopic disease. Microscopic residual disease (MRD) can lead to increased risk for local recurrence (LR) and reduced overall survival. Currently no methods exist to intraoperatively assess whether individual cancer cells remain in the tumor bed; only post-operative pathologic evaluation of the tumor for molecular tumor markers, requiring several days in a laboratory setting, can definitely identify MRD. Over 50,000 women each year who are diagnosed with breast cancer are found to have MRD after lumpectomy. Elimination of MRD in breast cancer is known to reduce the need for second surgical procedures, halve the LR rate from 30% to 15%, and increase breast cancer survival. A method of imaging MRD intraoperatively to guide complete resection is therefore essential. This project seeks to develop one method for intraoperatively identifying MRD.

BIOGRAPHY
Efthymios is a Ph.D. student in integrated circuits in Prof. Bernhard Boser's research group. He is co-adviced by Prof. Mekhail Anwar, M.D. of UCSF. He graduated from Columbia University in Spring of 2014 with a B.Sc. degree. His research interests are circuits for biomedical applications and he is currently working on a micro fluorescence imager for breast cancer detection.

Real-Time Intraoperative Fluorescent Imager for Microscopic Residual Tumor in Breast Cancer [BPN685]
Successful treatment of early stage cancer depends on the ability to resect both gross and microscopic disease. Microscopic residual disease (MRD) can lead to increased risk for local recurrence (LR) and reduced overall survival. Currently no methods exist to intraoperatively assess whether individual cancer cells remain in the tumor bed; only post-operative pathologic evaluation of the tumor for molecular tumor markers, requiring several days in a laboratory setting, can definitely identify MRD. Over 50,000 women each year who are diagnosed with breast cancer are found to have MRD after lumpectomy. Elimination of MRD in breast cancer is known to reduce the need for second surgical procedures, halve the LR rate from 30% to 15%, and increase breast cancer survival. A method of imaging MRD intraoperatively to guide complete resection is therefore essential. This project seeks to develop one method for intraoperatively identifying MRD.


Current Active Projects:
BPN685
 

     Last Updated: Tue 2015-Jun-23 10:44:02

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