Research Interests: BioMEMS, Biomedical devices, and nanotechnology.
Bochao Lu received his B.S. in Bioengineering&Material Science Engineering Joint major from UC Berkeley in 2014. His undergraduate research projects include the role of Sox10 lineage cells in scar formation and digit regeneration, the effect of nanotopography on multipotent vascular stem cells (MVSCs), mesenchymal stem cells (MSCs) induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) differentiation. He joined the joint bioengineering PhD program at UC Berkeley - UCSF in 2014. Bochao’s current research interest focuses on fast detection of low-concentration biomarkers on the basis of nanofluidic chips.
Cytokine Fast Detection [BPN816]
Sepsis is a life-threatening condition both in civilian and military medical scenarios. Patients with sepsis usually
exhibit a vigorous systemic release of cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis
factor (TNF) into serum. The ability to monitor relative cytokine levels continuously at fast time scales (tens of
minutes) could open the door to closed-loop, patient-specific sepsis management therapies. The current methods
of cytokine detection take hours and cost thousands of dollars because the physiological concentration is so low
around femtomolar. At such low concentrations, the limiting factor becomes mass transport instead of binding
kinetics, due to increased diffusion length from bulk solution to sensor surface. We present a method, based on
nanofabrication and ion concentration polarization (ICP) which enriches analytes using only a DC power supply.