Fall 2010 IAB
September 15 to 17

Plenary 6: Adrienne Higa

Mechanical Regulation of Collective Cell Behavior via Microtopographic Substrates

While single cell studies have historically been the driving force for cell biology, group, or collective cell, behavior is actually the true working mechanism of the majority of practical applications, including tissue engineering, wound healing, and organ regeneration. Mechanical micro-environment cues have been demonstrated as important regulators of single cell behavior, and this project focuses on investigating mechanical regulation of collective cell behavior via microtopographic substrates.
Specifically, using micropost arrays with varying radii, substrates of variable stiffness can be generated to characterize stiffnesses to induce collective-to-single-cell transitions. This technique offers a simple and robust in vitro methodology for studying mechanical regulation of cellular behavior on chemically identical surfaces.