BERKELEY SENSOR & ACTUATOR CENTER
UC BERKELEY UC DAVIS
User: Guest |  Site Map |  My BSAC Profile
HOME  PROJECTS  THRUSTS  PUBLICATIONS  ABOUT BSAC  DIRECTORY  ALUMNI  FOR BSAC RESEARCHERS  EVENTS CALENDAR  SECURE LOGIN
Maboudian
     
 Lee
 Lin
 Wu
 

BPN500: Inkjet Interfaces for Controlling Biological Pattern Formation

Project ID BPN500
Website
Start Date Thu 2009-Jan-29 12:18:49
Last Updated Tue 2009-Aug-11 00:46:56
Abstract We have successfully adapted a consumer-grade inkjet printer for use as a means of controlling spatio-temporal gene expression in 2D cell culture. Specifically, we take advantage of a high-resolution printer designed to print on the surface of CDs. By modifying CD surfaces to contain customized Petri dish wells, we are able to culture E. coli in the wells and print various morphogens onto the surface of the culture. By varying the geometry of printed patterns of lactose and glucose we have demonstrated spatiotemporal control over the genetic activity of the lac operon. Having successfully demonstrated the technology, we are now examining the wide array of interesting dynamic effects we encountered such as propagating mRNA waves and counter-diffusion boundary control. We are also examining the possibility of adapting this system for use with mammalian cells. Current mammalian culture systems cannot produce 2D gradients within the culture material, meaning that an inkjet system capable of doing this would open up a number of interesting research areas.
Status Continuing
Funding Source
IAB Research Area BioMEMS
Researcher(s) Daniel Cohen
Advisor(s) Michel Maharbiz
Detailed Information
Secure Access

Private Abstract
Research Report
Poster
Summary Slide PDF | VIDEO
Active Feedback (or Request for Response)

 

  • Copyright Notification: All papers downloaded from this site are © University of California or the publisher, all rights reserved. Contact the BSAC Webmaster for permission related to copyrighted materials.
  • Links on these pages to commercial sites do not represent endorsements by UC or its affiliates.
  • Privacy Policy
  • Contact Us

   webmaster@bsac.eecs.berkeley.edu
  User logged in as: Guest
  User Idle since: October 22, 2014, 8:53 pm