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BPN685: Real-Time Intraoperative Fluorescent Imager for Microscopic Residual Tumor in Breast Cancer

Project ID BPN685
Website
Start Date Tue 2012-Aug-14 14:33:13
Last Updated Thu 2016-Jan-21 15:30:45
Abstract Successful treatment of early stage cancer depends on the ability to resect both gross and microscopic disease, yet no method exists to identify residual cancer cells intraoperatively. This is particularly problematic in breast cancer, where microscopic residual disease can double the rate of cancer returning, from 15% to 30% over 15 years, affecting a striking 37,500 women annually. Currently, residual disease can only be identified by examining excised tumor under a microscope, visualizing tumor cells stained with specific tumor markers. This microscopic evaluation restricts identification of tumor cells to the post-operative setting. Unfortunately, traditional optics cannot be scaled to the sub-centimeter size necessary to fit into the cavity and be readily manipulated over the entire surface area. To solve this problem, we have developed an imaging strategy that forgoes external optical elements for focusing light and instead uses angle-selective grids patterned in the metal interconnect of a standard CMOS process.
Status Continuing
Funding Source ASCO, DoD, and Mary Kay Foundation
IAB Research Area BioMEMS
Researcher(s) Efthymios P. Papageorgiou
Advisor(s) Bernhard E. Boser, Mekhail Anwar
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