| Project ID |
BPN699 |
| Website |
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| Start Date |
Thu 2013-Jan-03 10:26:17 |
| Last Updated |
Mon 2013-Mar-04 17:50:35 |
| Abstract |
Truly large-scale electrophysiology simultaneous recording of thousands of individual neurons in multiple brain areas remains an elusive goal of systems neuroscience. The traditional approach of studying single neurons in isolation assumes that the brain can be understood one component at a time. However, in order to fully understand the function of whole brain circuits it is essential to observe the interactions of large numbers of neurons in multiple brain areas simultaneously with high spatiotemporal resolution. This project will establish a complete system for multi-scale electrophysiology in awake, freely behaving mice, using state-of-the-art nano neural interfaces comprising of tiny silicon probes integrated with on- chip optical waveguides and compliant monolithic polymer cables connected a unique light- weight head-mounted recording system built around a commercially available application specific integrated circuit (ASIC) that has been custom designed for electrophysiological recordings, combining signal amplification, filtering, signal multiplexing, and digital sampling on a single chip. With this technology, optogenetic excitation or inhibition of neurons can occur simultaneously with the recording of large ensembles of individual neurons in many different brain regions. The diminutive size of the proposed instrument will revolutionize studies of the neuronal correlates of behavior, especially in small animals such as mice. Beyond fundamental neuroscience research, results from this project will further advance the development of next- generation neural prosthetic devices. |
| Status |
New |
| Funding Source |
NSF |
| IAB Research Area |
BioMEMS |
| Researcher(s) |
Maysamreza Chamanzar |
| Advisor(s) |
Michel Maharbiz, Tim Blanche |
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