||Wed 2014-Jan-22 15:18:04
||Tue 2017-Jan-31 15:59:17
||The unique properties of blood flow in microchannels has been studied for nearly a century; much of the
observed blood-specific dynamics is attributed to the biconcave shape of red blood cells. However, for almost twice
as long biologists have observed and characterized the differences in size and shape of red blood cells among
vertebrates. With a few exceptions, mammals share the denucleated biconcave shape of erythrocytes but vary in
size; oviparous vertebrates have nucleated ovoid red blood cells with size variations of a full order of magnitude.
We utilize micro-PIV and pressure drop measurements to analyze blood flow of vertebrate species in microchannels,
with a focus on understanding how cell size and shape alter the cell-free layer and velocity profile of whole blood.
The results offer insight into the Fahraeus-Lindqvist effect and the selection of animal blood for the design and
evaluation of biological microfluidic devices.
|IAB Research Area
||Kathryn Fink, Karthik Prasad