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BPN773: High-Throughput hiPS-HP-based Organ-on-a-chip Platforms for Drug Development

Project ID BPN773
Website
Start Date Thu 2014-Aug-14 00:57:53
Last Updated Thu 2014-Aug-14 15:22:02
Abstract Drug discovery and development is hampered by high failure rates attributed to reliance on non-human animal models employed during safety and efficacy testing. On the other hand, with conventional cell culture technology, as in vitro models of clinical behavior, isolated cells often rapidly lose tissue specific functions. With the discovery of human induced pluripotent stem (hiPS) cells, the tissue engineering community is now in position to develop in vitro model tissues to be used for high content drug screening and patient specific medicine. The use of human tissues organized into microphysiological analysis platforms could have an enormous impact on the early screening of candidate drugs. In this project we engineer a microfluidic in vitro platform based on the reconstitution of synthetic models of human liver with populations of hiPS cells differentiated into hepatocytes (hiPS-HPs). This platform can recapitulate the functional behavior of the liver tissue and is suitable for drug toxicity screening and hepatic disease modeling. We envision expanding this work into modeling other organs such pancreas, brain, and lung.
Status New
Funding Source NIH
IAB Research Area Microfluidics
Researcher(s) Alireza Salmanzadeh
Advisor(s) Luke Lee
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