BERKELEY SENSOR & ACTUATOR CENTER
UC BERKELEY UC DAVIS
User: Guest |  Site Map |  My BSAC Profile
HOME  PROJECTS  THRUSTS  PUBLICATIONS  ABOUT BSAC  DIRECTORY  ALUMNI  FOR BSAC RESEARCHERS  EVENTS CALENDAR  SECURE LOGIN
Table of all Projects
     
 

BPN807: Integrated Molecular Diagnostic System for Alzheimer’s Disease

Project ID BPN807
Website
Start Date Mon 2015-Aug-24 22:38:58
Last Updated Mon 2016-Feb-01 16:18:16
Abstract Amyloid beta (Aβ) is one of most crucial neuropathological biomarkers in Alzheimer's disease (AD). Up to date, the relation between the progress of the disorder and the interchange of Aβ level in the blood is still controversial; however, increasing evidence for transport of Aβ across the brain blood barrier (BBB) provides the linkage between concentrations of Aβ in central nervous system (CNS) and blood plasma. Hence, quantifying the Aβ level in blood plasma is considered as an emerging diagnostic method for AD. Here, we describe an integrated molecular diagnostic system (iMDx) for Aβ detection based on a dark-field microscope with single nanoparticle resolution. We obtain a sensitive plasmonic sandwich immunoassay for Aβ detection with a single nanoparticle resolution. We quantify simultaneously Aβ 1-40 and Aβ 1-42 on chip and characterize selectivity. We demonstrate the function of sample-to-answer iMDx that enables the portable diagnosis for Aβ level from whole blood by plasma separation. Hence, proposed iMDx could be a promising point-of-care tool for an early diagnosis of AD.
Status Continuing
Funding Source Foundation
IAB Research Area NanoPlasmonics, Microphotonics & Imaging
Researcher(s) Jin-Ho Lee, Ju-Young Byun, Jun Ho Son, Sang Hun Lee
Advisor(s) Luke P. Lee
Detailed Information
Secure Access

Private Abstract
Research Report
Poster
Summary Slide PDF | VIDEO
Active Feedback (or Request for Response)

 

  • Copyright Notification: All papers downloaded from this site are © University of California or the publisher, all rights reserved. Contact the BSAC Webmaster for permission related to copyrighted materials.
  • Links on these pages to commercial sites do not represent endorsements by UC or its affiliates.
  • Privacy Policy
  • Contact Us

   webmaster@bsac.eecs.berkeley.edu
  User logged in as: Guest
  User Idle since: December 11, 2017, 4:38 pm