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BPN846: 3D Printed Biomedical and Diagnostic Systems

Project ID BPN846
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Start Date Wed 2016-Aug-24 00:18:59
Last Updated Thu 2017-Aug-10 10:30:36
Abstract Enzyme-linked immunosorbent assay (ELISA) kits have wide applications in medical diagnostics, quality-control of produce, and toxicology. These kits, however, are expensive, highly complex, and require large sample volumes in order to process data. To overcome these drawbacks, microfluidic lab-on-chip platforms have been developed to quantify antibody-antigen binding interactions using microlitre volumes of analyte. These devices rely on standard soft-lithography or MEMS-based manufacturing methods, which are becoming increasingly more time consuming, labor intensive, and costly in the face of additive manufacturing processes. Additionally, current methods rely on immunofluorescence or chromogenic detection to measure antibody-antigen binding success, but these methods are time consuming, expensive, or subject to cross-reactivity or biofouling. We aim to develop a novel fully 3D printed thermoelectric biosensor for antibody-antigen binding quantification as an alternative micro-ELISA diagnostic tool. In this project, we will demonstrate that our 3D printed thermoelectric device can detect the streptavidin-biotin binding interaction as an initial proof-of-concept. Previous thermoelectric sensors for detection of bioreactions utilize non- biocompatible materials, which require the thermopile to be placed away from the channel, resulting in lower sensitivity systems. Utilizing a biocompatible PEDOT:PSS-based composite as our thermoelectric material, we aim to integrate the thermopile into the microchannel itself. Additionally, 3D printing will enable us to design 3D thermopile geometries that cannot be otherwise achieved with traditional soft-lithography. By eliminating the need for optics or external energy sources coupled with the use of low-cost additive manufacturing, we aim to develop a simple lab-on- chip alternative to traditional ELISA kits.
Status Continuing
Funding Source BSAC Member Fees
IAB Research Area Microfluidics
Researcher(s) Jacqueline Elwood, Eric C. Sweet, Ryan Jew
Advisor(s) Liwei Lin
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