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BPN893: 3D Printed Microfluidic Devices for Circulating Tumor Cell Isolation

Project ID BPN893
Website
Start Date Sun 2018-Jan-28 20:41:19
Last Updated Mon 2018-Jan-29 09:50:28
Abstract There are 90% of all cancer-related deaths that are caused by cancer metastasis. In these cases, cancer cells detach from a tumor, enter blood vessels, and circulate in human peripheral blood. These tumor cells are called circulating tumor cells (CTCs), which have the potential to invade and colonize in a distal site, resulting in patients' death. Thus, there is an urgent need for detection of CTCs to enable early treatment. In this research, a 3D printed microstructured (mesh-like) devices are developed for CTCs isolation from human blood. The microstructured surfaces will be covalently modified with antibodies for specific capture of CTCs. And, tumor cells (SW 480 and 293T) will be used to investigate the isolation performance of our fabricated 3D printed devices. This study will have wide application in multiple aspects of cancer diagnosis.
Status New
Funding Source Industry
IAB Research Area Microfluidics
Researcher(s) Juhong Chen
Advisor(s) Liwei Lin
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