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BPN774: Applications of 3D Printed Integrated Microfluidic Circuitry, Finger-Powered Pumps, and Mixers

Project ID BPN774
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Start Date Thu 2014-Aug-14 19:52:12
Last Updated Thu 2017-Aug-10 10:28:21
Abstract In this ongoing project we have previously developed a new class of three-dimensional modular fluidic operators (i.e. fluidic diodes, capacitors and transistors); passive 3D internally-rifled mixers; and have previously demonstrated low- cost one-way pumping and mixing systems powered solely by the operatorís finger. Currently, we aim to develop our easy-to-fabricate 3D microfluidic systems into functional biosensors via straight-forward integration with conductive polymer electrodes. Here, we present our preliminary investigations into the development of entirely 3D printed microfluidic salivary point-of-care diagnostic tools, specifically for the determination of salivary alcohol content (SAC) and salivary lactate content (SLC). In law enforcement, blood alcohol content (BAC) is routinely determined indirectly by measurement of breath alcohol content (BrAC) using commercialized breathalyzer technology. However, measurement of SAC has a nearly 1:1 correlation with BAC, much closer than BAC:BrAC, over 2,000:1. Therefore, SAC could prove to be a more reliable metric of sobriety than BrAC. In addition, for diabetic patients, continuous home monitoring blood glucose levels necessitates repeated finger pricking and blood testing. However, researchers have previously established measurable correlations between salivary lactic acid levels and blood glucose levels, opening the possibility for non-invasive, point-of-care salivary-based blood sugar monitoring. In this project, we aim to demonstrate proof-of-concept salivary diagnostic prototypes comprised of our previously-demonstrated 3D microfluidic technology and composite conductive polymer electrodes. SAC will be determined via pH-sensitive PEDOT:PSS/PANI polymer electrodes, and SLC will be determined via hydrogen peroxide-sensitive PEDOT:PSS/PAA polymer electrodes. Upon further development, such designs could prove critical tools in resolving the foremost commercial limitations of conventional microfluidic point-of-care diagnostic devices, specifically for salivary diagnostics.
Status Continuing
Funding Source BSAC Member Fees
IAB Research Area Microfluidics
Researcher(s) Eric Sweet, Jacqueline Elwood, Ryan Jew, Rudra Mehta
Advisor(s) Liwei Lin
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