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BPN926: Wireless Implantable Fluorescence Imager for Microscopic Residual Tumor in Breast Cancer

Project ID BPN926
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Start Date Wed 2019-Aug-07 09:31:34
Last Updated Sun 2020-Aug-09 22:11:39
Abstract Modern cancer treatment faces the pervasive challenge of identifying microscopic cancer foci in vivo to eliminate the risk of cancer recurrence due to the presence of the tumor cells left in the body after the surgery known as microscopic residual disease (MRD). Untreated MRD doubles the local recurrence of cancer limiting the survival rate of cancer surgeries. MRD can be overcome either by doing a more extensive resection on the patients at the cost of removing healthy tissue or by treating them with postoperative radiation therapy resulting in short and long term side effects. Modern biomarkers provide robust fluorescence images from the targets inside the body, nevertheless, they rely on bulky optical devices to operate. Consequently, an implantable fluorescence imager sensor that can both image small cavities of tumor cells intraoperatively and examine the tumor bed postoperatively to visualize any recurrence of tumor cells is critically needed. Moreover, a miniaturized laser diode is essential to illuminate the tumor bed to propose a fully implantable system than can operate inside the patients body. This project leverages siliconís optical features to operate at NIR wavelengths together with high transfer power density of ultrasound waves inside tissue to introduce an implantable imager that can provide a precise assessment of microscopic tumor residuals while operating standalone inside the body. As a result, we can provide surgeons with real-time information on the existence of any residual tumor cells in the patient in any possible stage during cancer treatment process, from early examination and detection to the operating room and postoperative monitor.
Status New
Funding Source Federal
IAB Research Area Wireless, RF & Smart Dust
Researcher(s) Rozhan Rabbani, Rebekah Zhao
Advisor(s) Bernhard E. Boser, Mekhail Anwar
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