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The January BSAC Research Seminar Series will feature Dr. SoonGweon Hong of BSAC Co-Director Prof. Luke Lee research lab.
New Drug Discovery Platforms and Organ-on-a-Chip Models
The presentation will focus on physiologically-modeled drug discovery platforms for various human organs. To avoid high costs and health risks caused by unexpected drug failures, there is a critical need for new drug discovery methods. Micro- and nanoscale engineering enabling precise microphysiological regulation is recognized as a potential approach to facilitate new drug discovery with better biological understanding. Two neuropathological models will be presented: an organoid minibrain model in physiological microfluidics and a vertebrate model representing human brain diseases. These models are integrated with unique electrical interfaces for real-time monitoring of brain development and neuropathology. Other human organ models will be presented including liver, heart and pancreas, which allow a precise characterization of drug effects on individual organs. A novel nanofluidic approach capable of assessing molecular accessibility into intracellular space especially for efflux pump-based drug resistant bacteria will conclude the presentation.
Dr. Hong joined BSAC and Prof. Lee's group as a graduate research student in 2008 and is currently a project scientist. His doctoral research focused on nano-optics and biological applications. After receiving his Ph.D. in 2012, he participated in developing drug discovery platforms recapitulating human physiology/pathology and precisely assessing drug-resistant pathogens through the organ-on-a-chip concept and micro/nanofluidics.