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Dr. Jun Ho Son

Bioengineering
Advisor: Prof. Lee
(510) 666-3352

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Research Interests: Point-of-care diagnostics Micro/Nano fabrication Optoelectronics
Job Interests: Academic

BIOGRAPHY
Ph.D. (2010), B.S. (2006), Materials Science and Engineering
Pohang University of Science and Technology (POSTECH)

Microfluidic Blood Plasma Separation for Point-of-Care Diagnostics [BPN730]
Microfluidic lab-on-a-chip (LOC) device for point-of-care (POC) diagnostics have been widely
developed for the rapid detection of infectious diseases such as HIV, TB and Malaria. Blood plasma
separation is an initial step for most blood-based diagnostics. Although, centrifuge method is the
classical bench-top technique, it is time and labor intensive, and therefore, automation and integration
of blood plasma separation in the LOC device is ideal for POC diagnostics. Here, we propose a novel
microfluidic blood plasma separation device for POC diagnostics. A membrane filter for filtration was
positioned on top of a vertical up-flow channel (filter-in-top configuration) to reduce clogging of red
blood cells (RBCs) by gravity-assisted cells sedimentation to prevent hemolysis of RBCs. As a result,
separated plasma volume was increased about 4-fold (2.4 µL plasma after 20 min with human blood) and
hemoglobin concentration in separated plasma was decreased about 90 % due to the prevention of RBCs
hemolysis in comparison to a filter-in-bottom configuration. On-chip plasma contains ~90 % of protein and
~100 % of nucleic acids compared to off-chip centrifuged plasma, showing comparable target molecules
recovery. This investigation will lead to a simple and reliable blood plasma separation device that can
be utilized by individuals with minimal training in resource-limited environments for POC diagnostics.


Current Active Projects:
BPN730
BPN804
BPN805
BPN807
 

     Last Updated: Tue 2014-Sep-09 18:53:21

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